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ea0014p530 | (1) | ECE2007

The expression of the neuroprotective factor seladin-1 is up-regulated by thyroid hormones in human neuronal precursor cells, but not in mature neurons

Benvenuti Susanna , Luciani Paola , Cellai Ilaria , Deledda Cristiana , Saccardi Riccardo , Urbani Serena , Vannelli Gabriella B , Francini Fabio , Squecco Roberta , Serio Mario , Pinchera Aldo , Peri Alessandro

Thyroid hormones (TH) play a fundamental role during brain development by modulating the expression of different genes involved in neuronal differentiation, proliferation, migration, myelinization, and synapse formation. Seladin-1 (for SELective Alzheimers Disease INdicator-1) is a recently identified anti-apoptotic gene, which has been found to be down-regulated in brain regions affected by Alzheimers disease (AD). We hypothesized that seladin-1 might be a ...

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Endocrine Abstracts

The expression of the neuroprotective factor seladin-1 is up-regulated by thyroid hormones in human neuronal precursor cells, but not in mature neurons

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